Toxicology of Chlorinated Dibenzo-p-Dioxins
نویسندگان
چکیده
منابع مشابه
Toxicology of chlorinated dibenzo-p-dioxins.
Severe toxicological responses have been associated with certain chlorodibenzodioxins. One of these responses is chloracne, a folliculosis first associated with skin contamination by chlorohydrocarbons in 1899 (1)). Serious outbreaks of chloracne-like lesions associated with runaway reactions in the production of 2,4,5-trichlorophenol occurred in Germany in the early 1950's (2). 2,4,5Trichlorop...
متن کاملImmunological effects of chlorinated dibenzo-p-dioxins.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and structurally similar halogenated aromatic hydrocarbons cause a broad range of immunologic effects in experimental animals including decreased host resistance to infectious disease and suppressed humoral and cell-mediated immune responses. In the mouse, TCDD immunotoxicity has been shown to be an aryl hydrocarbon (Ah) receptor-dependent process. How...
متن کاملEnvironmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans.
Few environmental compounds have generated as much interest and controversy within the scientific community and in the lay public as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). Their ubiquitous presence in the environment and the risk of accidental exposure has raised concern over a possible threat of PCDDs or PCDFs to human health. The most extensively ...
متن کاملBIOANALYTICAL DEVELOPMENT OF A HOMOGENEOUS PHOSPHORESCENT IMMUNOASSAY FOR THE DETECTION OF POLY- CHLORINATED DIBENZO-p- DIOXINS
Ahomogeneous immunoassay for dioxins was developed using a phosphorescent label for detection. A dioxin derivative was conjugated to Pt-coproporphyrin. In the assay, when the antibodies against dioxin (DD3) were bound to the phosphorescent conjugate, the signal from Pt-coproporphyrin was
متن کاملStudies on the mechanism of toxicity of the chlorinated dibenzo-p-dioxins.
Concern about the potential health hazards resulting from environmental pollution by the chlorinated dibenzo-p-dioxins and dibenzofurans arises from our recognition of the extraordinary potency of these compounds as toxins and teratogens and their inadvertant dispersion in the environment as contaminants of chlorinated phenolic products. Questions concerning the extent of environment contaminat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1973
ISSN: 0091-6765
DOI: 10.2307/3428117